Spectroscopic study of the interaction between lycopene and bovine serum albumin

被引：22
|
作者：
Rodriguez Galdon, Beatriz [1 ]
Pinto Corraliza, Carmen [1 ]
Cestero Carrillo, Juan J. [1 ]
Macias Laso, Pedro [1 ]
机构：
[1] Univ Extremadura, Fac Sci, Dept Biochem & Mol Biol, Badajoz 06006, Spain
来源：
LUMINESCENCE | 2013年 / 28卷 / 05期
关键词：
lycopene; fluorescence; bovine serum albumin; antioxidants; LIPID-PEROXIDATION; BINDING MECHANISM; DNA-DAMAGE; FLUORESCENCE; CAROTENOIDS; PREVENTION; SITE; RED;
D O I：
10.1002/bio.2434
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The interaction of lycopene with bovine serum albumin (BSA) in aqueous solution was studied by fluorescence quenching, three-dimensional fluorescence and circular dichroism spectroscopy. The data showed that the fluorescence of BSA was quenched by lycopene at different temperatures through a dynamic mechanism. The evaluation of three-dimensional fluorescence spectra revealed a conformational modification of BSA induced by coupling with lycopene and an increase in protein diameter as a consequence of the ligand-protein interaction. Moreover, the information obtained from evaluation of the effect of lycopene on BSA conformation by circular dichroism strongly supported the existence of a slight unfolding of BSA induced by coupling to lycopene. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码：765 / 770
页数：6
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