Design, synthesis, biophysical and structure-activity properties of a novel dual MDM2 and MDMX targeting stapled a-helical peptide, ATSP-7041, that exhibits potent in vitro and in vivo efficacy in xenograft models of human cancer

被引：0

作者：

Guerlavais, V. ^{[1
]}

Graves, B. ^{[2
]}

Tovar, C. ^{[2
]}

Packman, K. ^{[2
]}

Olson, K. ^{[1
]}

Kesavan, K. ^{[1
]}

Gangurde, P. ^{[1
]}

Darlak, K. ^{[1
]}

Horstick, J. ^{[1
]}

Mukherjee, A. ^{[1
]}

Baker, T. ^{[1
]}

Shi, E. ^{[1
]}

Lentini, S. ^{[1
]}

Sun, K. ^{[1
]}

Irwin, S. ^{[1
]}

Feyfant, E. ^{[1
]}

To, T. ^{[2
]}

Filipovic, Z. ^{[2
]}

Elkin, C. ^{[1
]}

Pero, J. ^{[1
]}

Santiago, S. ^{[1
]}

Bruton, T. ^{[1
]}

Sawyer, T. ^{[1
]}

Annis, A. ^{[1
]}

Fotouhi, N. ^{[2
]}

Manning, T. ^{[1
]}

Nash, H. ^{[1
]}

Vassilev, L. T. ^{[2
]}

Chang, Y. S. ^{[1
]}

Sawyer, T. K. ^{[1
]}

机构：

[1] Aileron Therapeut Inc, Cambridge, MA USA

[2] Hoffman La Roche Inc, Roche Res Ctr, Nutley, NJ USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 245卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

63-MEDI

引用

页数：1

共 2 条

[1] ATSP-7041, a Dual MDM2 and MDMX Targeting Stapled A-helical Peptide Exhibits Potent in Vitro and in Vivo Efficacy in Xenograft Models of Human Cancer
Chang, Y.
Graves, B.
Guerlavais, V.
Vassilev, L.
Packman, K.
Olson, K.
Annis, A.
Tovar, C.
Nash, H.
Sawyer, T.
[J]. EUROPEAN JOURNAL OF CANCER, 2012, 48 : 68 - 69
[2] ATSP-7041: A Novel Stapled α-Helical Peptide Dual Inhibitor of MDM2 and MDMX Effective In Vivo for p53-Dependent Cancers
Sawyer, Tomi K.
[J]. BIOPOLYMERS, 2013, 100 (03) : 236 - 236

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