CRITERIA FOR AN UPDATED CLASSIFICATION OF HUMAN TRANSCRIPTION FACTOR DNA-BINDING DOMAINS

被引:7
|
作者
Wingender, Edgar [1 ,2 ]
机构
[1] Univ Med Ctr Groningen, Dept Bioinformat, D-37077 Gottingen, Germany
[2] geneXplain GmbH, D-38302 Wolfenbuttel, Germany
关键词
Transcription factors; DNA-binding domains; classification; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; COMPLEX REVEALS; GLUCOCORTICOID-RECEPTOR; PROTEIN; BOX; SEQUENCE; RECOGNITION; NOMENCLATURE; ELEMENT;
D O I
10.1142/S0219720013400076
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.
引用
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页数:21
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