Association of polymorphisms in the estrogen receptor β (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population

被引：17
|
作者：
Hu, Jingjing [1 ]
Wang, Jing [2 ]
Xiang, Huifeng [1 ]
Li, Zelian [1 ]
Wang, Binbin [2 ]
Cao, Yunxia [1 ]
Ma, Xu [2 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Ctr Reprod Med, Hefei 230022, Anhui, Peoples R China
[2] Natl Res Inst Family Planning, Beijing, Peoples R China
来源：
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷 / 09期
关键词：
Estrogen receptor beta gene; estrogen receptor beta; recurrent spontaneous abortion; single nucleotide polymorphism; FEMALE RAT-BRAIN; GALANIN EXPRESSION; ALPHA GENE; PREGNANCY; RISK; MISCARRIAGE; IDENTIFICATION; VARIANTS; NEURONS; DISEASE;
D O I：
10.3109/14767058.2012.663021
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: To investigate the association of 1082G > A(RsaI) (rs1256049) and 1730A > G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively - located on estrogen receptor beta (ESR2) gene with recurrent spontaneous abortion (RSA) in Chinese population. Methods: The study group consisted of 196 patients with RSA and 182 fertile women as control. Two functional polymorphisms 1082G > A (a silent mutation in exon 5) and 1730A > G (3' nontranslated region of the exon 8) of ESR2 were studied by association analysis. Results: There were no significant differences between ESR2 gene polymorphisms and RSA (chi(2) = 1.793, P = 0.408; chi(2) = 1.432, P = 0.489, respectively). Conclusion: The present data indicate that the studied SNPs on ESR2 gene may not be associated with RSA in Chinese population.
引用
收藏
页码：1727 / 1729
页数：3
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