SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW PYRIMIDINE DERIVATIVES

被引：6
|
作者：
El-mahdy, Kamelia M. [1 ]
El-Kazak, Azza M. [1 ]
机构：
[1] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt
来源：
HETEROCYCLES | 2013年 / 87卷 / 04期
关键词：
Hydrazinolysis; Pyrimido[2,1-c][1,2,4]triazine; Vilsmeier Reagent; Pyrazolecarbaldehyde; Thiazolidinylpyrimidine; CALCIUM-CHANNEL BLOCKERS; ANTIHYPERTENSIVE AGENTS; ACID-ESTERS; POTENT;
D O I：
10.3987/COM-13-12663
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 2-mercaptopyrimidine 1 with ethyl chloroacetate afforded isomeric pyrimidines 2 and 3. Interaction of 3 with bifunctional nitrogen nucleophiles yielded pyrimidotriazine 5 and 7. Hydrazinolysis of 2 by hydrazine hydrate afforded hydrazinopyrimidine 8. Treatment of 8 with acetophenone gave 9. Cyclization of 9 with Vilsmeier reagent afforded the pyrazole carbaldehyde 10. Interaction of 8 with benzylidenemalononitrile and/or ethyl ethoxymethylenecyanoacetate afforded the pyrazoles 11 and 12. The reaction of 8 with p-chlorobenzaldehyde yielded 13, which was cyclized with thioglycolic acid to give thiazolidinone 14. The biological activity of selected compounds was investigated.
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收藏
页码：841 / +
页数：12
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