Primary Central Nervous System Lymphoma Overview of Current Treatment Strategies

被引：26

作者：

Brastianos, Priscilla K. ^{[1
,2
]}

Batchelor, Tracy T. ^{[1
,3
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp Canc Ctr, Stephen E & Catherine Pappas Ctr Neurooncol, Div Hematol & Oncol,Dept Neurol,Med Sch, Boston, MA 02114 USA

[2] Harvard Univ, Dept Med Oncol, Dana Farber Brigham & Womens Canc Ctr, Sch Med, Boston, MA 02115 USA

[3] Harvard Univ, Dept Radiat Oncol, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2012年 / 26卷 / 04期

关键词：

Primary central nervous system lymphoma; Treatment; Chemotherapy; Radiation; PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; NON-HODGKINS-LYMPHOMA; WHOLE-BRAIN RADIOTHERAPY; STEM-CELL TRANSPLANTATION; RECURRENT PRIMARY CNS; MULTICENTER PHASE-II; RADIATION-THERAPY; INITIAL TREATMENT; INTRAVENTRICULAR CHEMOTHERAPY;

D O I：

10.1016/j.hoc.2012.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary central nervous system lymphoma (PCNSL) is an uncommon and aggressive variant of non-Hodgkin lymphoma that involves the brain, eyes, leptomeninges, or spinal cord. Therapeutic progress has been modest, and our understanding of the molecular mechanisms that drive this disease is limited. Clinicians treating PCNSL face a challenge to balance the need to administer aggressive regimens to achieve a cure with the risks of delayed neurotoxicity after treatment. The standard treatment is a methotrexate-containing chemotherapy regimen. The timing and dose of whole-brain radiation therapy is controversial, given the significant risks of late neurotoxic effects, particularly in elderly patients.

引用

页码：897 / +

页数：21

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