Effects of high molecular weight alcohols from sugar cane fed alone or in combination with plant sterols on lipid profile and antioxidant status of Wistar rats

被引:0
|
作者
Kitts, David D. [1 ]
Kopec, Aneta [2 ]
Zawistowski, Jerzy [1 ]
Popovich, David G. [3 ]
机构
[1] Univ British Columbia, Vancouver, BC V6T 1Z4, Canada
[2] Agr Univ Krakow, Dept Human Nutr, PL-30149 Krakow, Poland
[3] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
基金
加拿大自然科学与工程研究理事会;
关键词
hypercholesterolemia; sugar cane mixed alcohols; phytosterols; dyslipidemia; antioxidant status; LOW-DENSITY-LIPOPROTEIN; CHOLESTEROL-BIOSYNTHESIS; PLASMA-CHOLESTEROL; ALPHA-TOCOPHEROL; LDL-CHOLESTEROL; REDUCES PLASMA; BETA-CAROTENE; IN-VITRO; POLICOSANOL; PHYTOSTEROLS;
D O I
10.1139/H2012-072
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The effect of feeding a mixture of high molecular weight alcohols derived from sugarcane (SCA), both alone and in combination with phytosterols (PS), on changes in plasma lipids, organ cholesterol accumulation, and antioxidant status of Wistar rats was undertaken. Three separate experiments were conducted and each experiment had 3 subsets. In experiment 1, rats were fed on an AIN-76, semi-synthetic diet supplemented with 0%, 0.5%, and 5% SCA w/w. The second experiment consisted of feeding rats an atherogenic diet (AIN-76+0.5% cholesterol) containing 0%, 0.5%, and 5% SCA w/w. The third experiment consisted of feeding rats an atherogenic diet that contained 2% PS in combination with 0%, 0.5%, and 5% SCA. Rats fed the atherogenic diet exhibited significant elevations in total and low-density lipoprotein cholesterol, and significant reductions in the high-density lipoprotein/total cholesterol ratio, regardless of the presence of 0.5% or 5% SCA mixture. Serum cholesterol increased 29% to 35% in these animals compared with animals fed the nonatherogenic diets. In contrast, animals fed atherogenic diets that contained 2% PS exhibited no difference in serum lipids compared with counterparts fed nonatherogenic diets. The combined presence of SCA with PS had no effect on further lowering plasma cholesterol. No changes in C-reactive protein were observed, but plasma oxygen radical scavenging capacity values significantly (p < 0.05) decreased when rats were fed the atherogenic diets that contained the combination of PS and SCA. This result corresponded to an apparent greater (p < 0.05) susceptibility of red blood cells to oxidative stress
引用
收藏
页码:938 / 946
页数:9
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