Covid-19 Kills More Men Than Women: An Overview of Possible Reasons

被引：54
|
作者：
Capuano, Annalisa [1 ]
Rossi, Francesco [1 ]
Paolisso, Giuseppe [2 ]
机构：
[1] Univ Campania Luigi Vanvitelli, Reg Ctr Pharmacovigilance, Dept Expt Med, Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2020年 / 7卷
关键词：
Covid-19; mortality; gender difference; immune system; sex hormones; smoking habit; coagulation pattern; cardiovascular diseases; CORONAVIRUS DISEASE 2019; INNATE IMMUNE-RESPONSE; GENDER-DIFFERENCES; CLINICAL CHARACTERISTICS; INFECTION; SMOKING; SYSTEM; VIRUS; CHINA; CELLS;
D O I：
10.3389/fcvm.2020.00131
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The high mortality observed in Covid-19 patients may be related to unrecognized pulmonary embolism, pulmonary thrombosis, or other underlying cardiovascular diseases. Recent data have highlighted that the mortality rate of Covid-19 seems to be higher in male patients compared to females. In this paper, we have analyzed possible factors that may underline this sex difference in terms of activity of the immune system and its modulation by sex hormones, coagulation pattern, and preexisting cardiovascular diseases as well as effects deriving from smoking and drinking habits. Future studies are needed to evaluate the effects of sex differences on the prevalence of infections, including Covid-19, its outcome, and the responses to antiviral treatments.
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页数：7
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