Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease

被引：599
|
作者：
Hsieh, Sharpley [1 ]
Schubert, Samantha [1 ]
Hoon, Christopher [1 ]
Mioshi, Eneida [1 ,2 ]
Hodges, John R. [1 ,2 ]
机构：
[1] Neurosci Res Australia, Sydney, NSW, Australia
[2] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2013年 / 36卷 / 3-4期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
Alzheimer's disease; Cognitive screening test; Frontotemporal dementia; Neuropsychological tests; MENTAL-STATE-EXAMINATION; REVISED ACE-R; PROGRESSIVE APHASIA; BEHAVIORAL VARIANT; DIAGNOSIS; IMPAIRMENT; BATTERY; ASSOCIATION; DYSFUNCTION; UTILITY;
D O I：
10.1159/000351671
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD. (C) 2013 S. Karger AG, Basel
引用
收藏
页码：242 / 250
页数：9
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