Rabies vaccines: Current status and prospects for development

被引：7

作者：

Starodubova, E. S. ^{[1
]}

Preobrazhenskaia, O. V. ^{[1
]}

Kuzmenko, Y. V. ^{[1
]}

Latanova, A. A. ^{[1
]}

Yarygina, E. I. ^{[2
]}

Karpov, V. L. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Skryabin Moscow State Acad Vet Med & Biotechnol, Moscow 109472, Russia

来源：

MOLECULAR BIOLOGY | 2015年 / 49卷 / 04期

关键词：

rabies; rabies vaccine; glycoprotein; ATTENUATED RECOMBINANT RABIES; PROTECTIVE IMMUNE-RESPONSE; DNA VACCINE; VIRUS GLYCOPROTEIN; EXPRESSION; MICE; IMMUNOGENICITY; EFFICACY; DOGS; STRATEGIES;

D O I：

10.1134/S0026893315040172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rabies is an infectious disease among humans and animals that remains incurable, despite its longstanding research history. The only way to prevent the disease is prompt treatment, including vaccination as an obligatory component and administration of antirabies immunoglobulin as a supplement. Since the first antirabies vaccination performed in the 19th century, a large number of different rabies vaccines have been developed. Progress in molecular biology and biotechnology enabled the development of effective and safe technologies of vaccine production. Currently, new-generation vaccines are being developed based on recombinant rabies virus strains or on the production of an individual recombinant rabies antigen-glycoprotein (G protein), either as a component of nonpathogenic viruses, or in plants, or in the form of DNA vaccines. In this review, the main modern trends in the development of rabies vaccines have been discussed.

引用

页码：513 / 519

页数：7

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