Carrier molecules for use in veterinary vaccines

被引：31
|
作者：
Gerdts, Volker [1 ]
Mutwiri, George [1 ]
Richards, James [2 ]
Littel-van den Hurk, Sylvia van Drunen [1 ]
Potter, Andrew A. [1 ]
机构：
[1] Univ Saskatchewan, Int Vaccine Ctr, Vaccine & Infect Dis Org, Saskatoon, SK, Canada
[2] Natl Res Council Canada, Ottawa, ON, Canada
来源：
VACCINE | 2013年 / 31卷 / 04期
关键词：
Veterinary vaccine; Carrier; Conjugate; Nanoparticle; Microparticle; Virus-like particle; DEER CERVUS-ELAPHUS; IMMUNE-RESPONSES; ACTINOBACILLUS-PLEUROPNEUMONIAE; PROTEIN GLYCOSYLATION; CONJUGATE VACCINES; SURFACE PROTEIN; CORE PARTICLES; VIRUS; IMMUNIZATION; VACCINATION;
D O I：
10.1016/j.vaccine.2012.11.067
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The practice of immunization of animals and humans has been carried out for centuries and is generally accepted as the most cost effective and sustainable method of infectious disease control. Over the past 20 years there have been significant changes in our ability to produce antigens by conventional extraction and purification, recombinant DNA and synthesis. However, many of these products need to be combined with carrier molecules to generate optimal immune responses. This review covers selected topics in the development of carrier technologies for use in the veterinary vaccine field, including glycoconjugate and peptide vaccines, microparticle and nanoparticle formulations, and finally virus-like particles. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：596 / 602
页数：7
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