New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

被引：39

作者：

Zeng, Dexing ^{[1
]}

Ouyang, Qin ^{[2
]}

Cai, Zhengxin ^{[1
]}

Xie, Xiang-Qun ^{[2
]}

Anderson, Carolyn J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15219 USA

[2] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 01期

关键词：

BIOLOGICAL EVALUATION; RADIOPHARMACEUTICALS; DESIGN;

D O I：

10.1039/c3cc45928d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with Cu-64 under mild conditions in high specific activity. DBCO-PEG(4)-CB- TE1K1P was synthesized for conjugation to proteins, while Dde-CB- TE1K1P(Bu-t(2))-OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

引用

页码：43 / 45

页数：3