Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa

被引：39

作者：

Song, Wei-Hua ^{[1
]}

Cheng, Zhi-Hong ^{[1
]}

Chen, Dao-Feng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 01期

基金：

中国国家自然科学基金;

关键词：

COMPLEMENT-SYSTEM; NO PRODUCTION; GLYCOSIDES; PAEONIFLORIN; INHIBITION; PATHWAY;

D O I：

10.1021/np400571x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP(50), values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.

引用

页码：42 / 48

页数：7

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