Neuropsychological and neurobehavioral functioning in Duchenne muscular dystrophy: A review

被引:125
|
作者
Snow, Wanda M. [1 ]
Anderson, Judy E. [2 ]
Jakobson, Lorna S. [1 ]
机构
[1] Univ Manitoba, Dept Psychol, Fac Arts, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Dept Biol Sci, Fac Sci, Winnipeg, MB R3T 2N2, Canada
来源
基金
加拿大自然科学与工程研究理事会;
关键词
Duchenne muscular dystrophy; Dystrophin; Neuropsychology; Intelligence; Cognition; Verbal memory; Neurobehavioral; Neuropsychiatric; Social interaction; Autism; CENTRAL-NERVOUS-SYSTEM; VERBAL WORKING-MEMORY; COGNITIVE IMPAIRMENT; CHILDREN; BOYS; AUTISM; INTELLIGENCE; BEHAVIOR; DEFICITS; PROFILE;
D O I
10.1016/j.neubiorev.2013.03.016
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Duchenne muscular dystrophy (DMD) is a genetic condition affecting predominantly boys that is characterized by fatal muscle weakness. While there is no cure, recent therapeutic advances have extended the lifespan of those with DMD considerably. Although the physiological basis of muscle pathology is well-documented, less is known regarding the cognitive, behavioral, and psychosocial functioning of those afflicted. Several lines of evidence point to central nervous system involvement as an organic feature of DMD, challenging our view of the disorder as strictly neuromuscular. This report provides a review of the literature on neuropsychological and neurobehavioral functioning in DMD. Recent research identifying associations with DMD and neuropsychiatric disorders is also discussed. Lastly, the review presents implications of findings related to nonmotor aspects of DMD for improving the quality of life in those affected. While the literature is often contradictory in nature, this review highlights some key findings for consideration by clinicians, educators and parents when developing therapeutic interventions for this population. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:743 / 752
页数:10
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