Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

被引：113

作者：

Friedrichsen, Martin ^{[1
,2
]}

Mortensen, Brynjulf ^{[3
]}

Pehmoller, Christian ^{[1
]}

Birk, Jesper B. ^{[1
]}

Wojtaszewski, Jorgen F. P. ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Exercise & Sport Sci, August Krogh Ctr, Mol Physiol Grp, DK-2100 Copenhagen, Denmark

[2] Rigshosp, Dept Diabet & Metab, DK-2100 Copenhagen, Denmark

[3] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2013年 / 366卷 / 02期

基金：

英国医学研究理事会;

关键词：

AMPK; Skeletal muscle; Glucose metabolism; Insulin sensitivity; ACTIVATED PROTEIN-KINASE; ADENINE-NUCLEOTIDE DEGRADATION; GAMMA-SUBUNIT ISOFORMS; ACETYL-COA CARBOXYLASE; FATTY-ACID OXIDATION; AS160; PHOSPHORYLATION; GLUT4; TRANSLOCATION; GLYCOGEN-SYNTHASE; TBC1D1; 14-3-3; BINDING;

D O I：

10.1016/j.mce.2012.06.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：204 / 214

页数：11

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