Growing hyperbranched polyglycerols on magnetic nanoparticles to resist nonspecific adsorption of proteins

被引：51
|
作者：
Wang, Shixing [1 ]
Zhou, Yang [1 ]
Yang, Shengchun [1 ]
Ding, Bingjun [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Sci, Dept Mat Phys, Xian 710049, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2008年 / 67卷 / 01期
关键词：
Magnetic nanoparticles; Anionic ring-opening polymerization; Hyperbranched polyglycerols; Protein; Nonspecific adsorption;
D O I：
10.1016/j.colsurfb.2008.08.009
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Hyperbranched polyglycerols were grown from magnetic nanoparticles (MNPs) via surface-initiated anionic ring-opening polymerization of glycidol. The modified MNPs were characterized by using TEM, XPS,TGA and FTIR. Hyperbranched polyglycerols resist the nonspecific adsorption of proteins on magnetic nanoparticles. The capability of hyperbranched polyglycerols is comparable favorably with the performance of methyloxy poly(ethylene glycol) (a linear mPEG with a molecular weight of 750) in resisting the adsorption of proteins. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：122 / 126
页数：5
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