NHC-Catalyzed Hydroacylation of Styrenes

被引：77
|
作者：
Schedler, Michael [1 ]
Wang, Duo-Sheng [1 ]
Glorius, Frank [1 ]
机构：
[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 09期
关键词：
hydroacylation; N-heterocyclic carbenes; organocatalysis; styrenes; synthetic methods; N-HETEROCYCLIC CARBENES; DIRECT INTERMOLECULAR HYDROACYLATION; INTRAMOLECULAR STETTER REACTION; FORMING TRANSFER HYDROGENATION; ALDEHYDE OXIDATION LEVEL; ASYMMETRIC EPOXIDATION; BETA; GAMMA-UNSATURATED KETONES; NUCLEOPHILIC ORGANOCATALYSTS; ELECTROPHILIC BROMINE; ALKYNE HYDROACYLATION;
D O I：
10.1002/anie.201209291
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New hydroacylation catalysts: Highly electron-rich N-heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron-withdrawing group, EDG=electron-donating group. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2585 / 2589
页数：5
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