Exposure to ambient air particulate matter and non-alcoholic fatty liver disease

被引:44
|
作者
Tarantino, Giovanni [1 ,2 ]
Capone, Domenico [3 ]
Finelli, Carmine [4 ]
机构
[1] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, I-80131 Naples, Italy
[2] INT Fdn Pascale Canc Res Ctr Mercogliano, I-83013 Mercogliano, Italy
[3] Univ Naples Federico II, Med Sch Naples, Dept Neurosci, Clin Pharmacol Unit, I-80131 Naples, Italy
[4] Stella Maris Mediterraneum Fdn, Ctr Obes & Eating Disorders, I-80035 Potenza, Italy
关键词
Non-alcoholic fatty liver disease; Particulate matter with aerodynamic diameters < 2.5 mu m; Cytochrome P-450; Reactive oxygen species; ACTIVATED PROTEIN-KINASE; DIESEL EXHAUST PARTICLES; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; DAILY MORTALITY; RISK-FACTORS; POLLUTION; ASSOCIATIONS; RESPONSES;
D O I
10.3748/wjg.v19.i25.3951
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The present study was designed to alert the public opinion and policy makers on the supposed enhancing effects of exposure to ambient air particulate matter with aerodynamic diameters < 2.5 mm (PM2.5) on nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western countries. For far too long literature data have been fixated on pulmonary diseases and/or cardiovascular disease, as consequence of particulate exposure, ignoring the link between the explosion of obesity with related syndromes such as NAFLD and air pollution, the worst characteristics of nowadays civilization. In order to delineate a clear picture of this major health problem, further studies should investigate whether and at what extent cigarette smoking and exposure to ambient air PM2.5 impact the natural history of patients with obesity-related NAFLD, i.e., development of non alcoholic steatohepatitis, disease characterized by a worse prognosis due its progression towards fibrosis and hepatocarcinoma. (C) 2013 Baishideng. All rights reserved.
引用
收藏
页码:3951 / 3956
页数:6
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