Skin barrier function and allergic risk

被引：151

作者：

Hudson, TJ ^{[1
]}

机构：

[1] AllerGen Network, Montreal, PQ, Canada

[2] McGill Univ, Montreal, PQ, Canada

[3] Genome Quebec Innovat Ctr, Montreal, PQ, Canada

来源：

NATURE GENETICS | 2006年 / 38卷 / 04期

关键词：

D O I：

10.1038/ng0406-399

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new study reports that two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis, and interestingly, for asthma in association with atopic dermatitis, but not asthma in the absence of atopic dermatitis. These findings suggest the importance of the epidermal barrier in preventing sensitization to allergens.

引用

页码：399 / 400

页数：2

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