Multi-component reactions and evolutionary chemistry

被引：338
|
作者：
Weber, L [1 ]
机构：
[1] Morphochem, D-81379 Munich, Germany
来源：
DRUG DISCOVERY TODAY | 2002年 / 7卷 / 02期
关键词：
D O I：
10.1016/S1359-6446(02)00010-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.
引用
收藏
页码：143 / 147
页数：5
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