After reionization, emission in the 21 cm hyperfine transition provides a direct probe of neutral hydrogen distributed in galaxies. Different from galaxy redshift surveys, observation of baryon acoustic oscillations in the cumulative 21 cm emission may offer an attractive method for constraining dark energy properties at moderate redshifts. Keys to this program are techniques to extract the faint cosmological signal from various contaminants, such as detector noise and continuum foregrounds. In this paper, we investigate the possible systematic and statistical errors in the acoustic scale estimates using ground-based radio interferometers. Based on the simulated 21 cm interferometric measurements, we analyze the performance of a Fourier-space, light-of-sight algorithm in subtracting foregrounds, and further study the observing strategy as a function of instrumental configurations. Measurement uncertainties are presented from a suite of simulations with a variety of parameters, in order to have an estimate of what behaviors will be accessible in the future generation of hydrogen surveys. We find that 10 separate interferometers, each of which contains similar to 300 dishes, observing an independent patch of the sky and producing an instantaneous field of view (FOV) of similar to 100 deg(2), can be used to make a significant detection of acoustic features over a period of a few years. Compared to optical surveys, the broad bandwidth, wide FOV, and multi-beam observation are all unprecedented capabilities of low-frequency radio experiments.