The complex genetics in autism spectrum disorders

被引：6
|
作者：
Hua Rui [1 ,2 ]
Wei MengPing [1 ,2 ]
Zhang Chen [1 ,2 ]
机构：
[1] Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
[2] Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2015年 / 58卷 / 10期
基金：
中国国家自然科学基金;
关键词：
autism spectrum disorders; genetics; causative genes; copy number variants; FRAGILE-X-SYNDROME; METABOTROPIC GLUTAMATE-RECEPTOR; MENTAL-RETARDATION PROTEIN; ENCODING NEUROLIGINS NLGN3; MOUSE MODEL; RETT-SYNDROME; ANGELMAN-SYNDROME; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; GABA(A) RECEPTOR;
D O I：
10.1007/s11427-015-4893-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Autism spectrum disorders (ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants (CNVs), linkage regions, and microRNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis.
引用
收藏
页码：933 / 945
页数：13
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