Internalization of DMSA-Coated Fe3O4 Magnetic Nanoparticles into Mouse Macrophage Cells

被引：3
|
作者：
Liu, Yingxun [1 ]
Chen, Zhongping [1 ]
Wang, Jinke [1 ]
机构：
[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
来源：
FUTURE MATERIAL RESEARCH AND INDUSTRY APPLICATION, PTS 1 AND 2 | 2012年 / 455-456卷
关键词：
Fe3O4 magnetic nanoparticles; DMSA; macrophage cell; internalization; ANIONIC SUPERPARAMAGNETIC NANOPARTICLES; IRON-OXIDE; INTRACELLULAR UPTAKE;
D O I：
10.4028/www.scientific.net/AMR.455-456.1221
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
This study observed the internalization of Fe3O4 magnetic nanoparticles (MNPs) coated with meso-2, -3-dimercaptosuccinnic acid (DMSA) into mouse macrophage RAW264.7 by using transmission electron microscopy (TEM) and Prussian blue staining. The results showed that the DMSA-coated Fe3O4 MNPs could be efficiently internalized into RAW264.7 cells. The internalized DMSA-coated Fe3O4 MNPs located in the cytoplasmic inclusions. The internalization of DMSA-coated Fe3O4 MNPs did not significantly affect the cell viability at given doses (20, 30, 40, 50 and 100 mu g/mL) and incubation times (2, 12, 24, 48 and 72 hours), suggesting DMSA-coated Fe3O4 MNPs had better biocompatibility. This study demonstrated that DMSA-coated Fe3O4 MNPs may provide a potential nanomaterial for biomedical applications.
引用
收藏
页码：1221 / 1227
页数：7
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