Translational Bioinformatics: Data-driven Drug Discovery and Development
被引:14
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作者:
Butte, A. J.
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机构:
Stanford Univ, Dept Pediat, Sch Med, Div Syst Med, Stanford, CA 94305 USA
Lucile Packard Childrens Hosp, Palo Alto, CA USAStanford Univ, Dept Pediat, Sch Med, Div Syst Med, Stanford, CA 94305 USA
Butte, A. J.
[1
,2
]
Ito, S.
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机构:
Hosp Sick Children, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, CanadaStanford Univ, Dept Pediat, Sch Med, Div Syst Med, Stanford, CA 94305 USA
Ito, S.
[3
]
机构:
[1] Stanford Univ, Dept Pediat, Sch Med, Div Syst Med, Stanford, CA 94305 USA
[2] Lucile Packard Childrens Hosp, Palo Alto, CA USA
[3] Hosp Sick Children, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada
Internet-accessible computing power and data-sharing mandates now enable researchers to interrogate thousands of publicly available databases containing molecular, clinical, and epidemiological data. With emerging new approaches, translational bioinformatics can now provide answers to previously untouchable questions, ranging from detecting population signals of adverse drug reactions to clinical interpretation of the whole genome. There are challenges, including lack of access to some data sources and software, but there are also overwhelming doses of hopes and expectations.
机构:
Icahn Sch Med Mt Sinai, Ctr Biomed Informat, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Ctr Biomed Informat, New York, NY 10029 USA
Readhead, Ben
Dudley, Joel
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机构:
Icahn Sch Med Mt Sinai, Ctr Biomed Informat, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl,Box 1498, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Ctr Biomed Informat, New York, NY 10029 USA