Parallel kinetic resolution of active esters using a quasi-enantiomeric combination of (R)-4-phenyl-oxazolidin-2-one and (S)-4,5,5-triphenyl-oxazolidin-2-one

被引：6
|
作者：
Coulbeck, Elliot [1 ]
Eames, Jason [1 ]
机构：
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, Yorks, England
来源：
TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 19期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/j.tetasy.2008.09.012
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The parallel kinetic resolution of a series of racemic pentafluorophenyl 2-(4-aryl/phenyl)-propionates and -butanoates using a quasi-enantiomeric combination of (R)-4-phenyl-oxazolidin-2-one and (S)-4,5,5-triphenyl-oxazolidin-2-one is discussed. The levels of diastereoselectivity were excellent (86-98% de) leading to separable quasi-enantiomeric oxazolidin-2-one adducts in good yield. This methodology was used to resolve 2-phenyl propionic acid. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2223 / 2233
页数：11
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