High-performance liquid chromatographic assay for the simultaneous determination of sulfadoxine and pyrimethamine from whole blood dried onto filter paper

被引：41
|
作者：
Green, MD [1 ]
Mount, DL [1 ]
Nettey, H [1 ]
机构：
[1] CDCP, Div Parasit Dis, Natl Ctr Infect Dis, Publ Hlth Serv, Atlanta, GA 30333 USA
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 767卷 / 01期
关键词：
sulfadoxine; pyrimethamine;
D O I：
10.1016/S0378-4347(01)00547-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A method using solid-phase extraction and high-performance liquid chromatography is evaluated for the simultaneous determination of sulfadoxine and pyrimethamine from 0.1 ml of whole blood dried onto filter paper. Extraction recoveries are about 60% for both drugs. The coefficient of variation for intra-assay precision, inter-assay precision and accuracy is less than 10% for sulfadoxine (10-100 mug/ml) and pyrimethamine (1-10 mug/ml). Published by Elsevier Science B.V.
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页码：159 / 162
页数：4
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