Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

被引：30
|
作者：
Yu, Jingxun [1 ]
Zhang, Zhihong [1 ]
Zhou, Shiqiang [1 ]
Zhang, Wei [1 ]
Tong, Rongbiao [1 ,2 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
[2] HKUST Shenzhen Res Inst, Shenzhen 518057, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 02期
关键词：
ISOQUINOLINE ALKALOIDS; PROTOBERBERINE ALKALOIDS; ENANTIOSELECTIVE SYNTHESIS; CATALYZED DECARBONYLATION; ANTIBACTERIAL ACTIVITY; TRANSFER HYDROGENATION; CARBOLINE ALKALOIDS; BERBERINE ANALOGS; TERMINAL ALKYNES; OXIDATION;
D O I：
10.1039/c7qo00776k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two synthetic routes have been developed for the asymmetric synthesis of tetrahydroprotoberberines, featuring installation of the asymmetry at an early stage of asymmetric redox-A(3) reaction and the late stage of asymmetric Noyori asymmetric transfer hydrogenation, respectively. This work is filling the gap between racemic and asymmetric syntheses of tetrahydroprotoberberines enabled by redox-A(3) reaction.
引用
收藏
页码：242 / 246
页数：5
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