FUNGAL METABOLITES AND ANTIMALARIAL DRUG DISCOVERY; A REVIEW

被引：0

作者：

Fatima, Nighat ^{[1
]}

Muhammad, Syed Aun ^{[2
]}

Qazi, Muneer Ahmed ^{[3
]}

Shah, Zia Ulallah ^{[4
]}

Khan, Abida K. ^{[5
]}

Maalik, Aneela ^{[5
]}

Rafique, Hummera ^{[6
]}

Mannan, Abdul ^{[1
]}

Dawood, Muhammad ^{[1
]}

Mumtaz, Amara ^{[5
]}

机构：

[1] COMSATS Inst Informat Technol, Dept Pharm, Abbottabad 22060, Pakistan

[2] Bahauddin Zakariya Univ, Inst Mol Biol & Biotechnol, Multan, Pakistan

[3] Shah Abdul Latif Univ, Dept Microbiol, Khairpur 66020, Sindh, Pakistan

[4] Sarhad Univ Sci & Informat Technol, Dept Pharm, Peshawar, Pakistan

[5] COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan

[6] Univ Gujrat, Dept Chem, Gujrat, Punjab, Pakistan

来源：

ACTA POLONIAE PHARMACEUTICA | 2017年 / 74卷 / 05期

关键词：

antimalarial; Plasmodium falcipanim; fungi; natural compounds; RESORCYLIC ACID LACTONES; OSTREA BCC 22955; ENDOPHYTIC FUNGUS; ANTIPLASMODIAL METABOLITES; HALOROSELLINIA-OCEANICA; MALARIA PARASITES; NATURAL-PRODUCTS; XYLARIA SP; SESQUITERPENES; CULTURES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Malaria is very dangerous and destructive parasitic infection in many underdeveloped countries. The current scenario of this disease is getting eviler. mainly due to the growing battle of Plasmodium falcipanun in contradiction of the pillar drug like chloroquine. There is a need of hours to discover novel drugs with unique structures and mechanism of action to treat drug resistant and sensitive strains of malaria. Natural products with unique structures are the major source for the lead discoveries and drug development against various diseases. This review presents recent advances and development in the field of new discoveries of antimalarial drug isolated from natural sources, especially fungi. This review covers investigation of fungal extracts. isolation and purification of chemically diverse secondary metabolites (macrolides. terpenes. peptides, xanthones and coumarines) exhibiting antimalarial activities. In sum these fungal metabolites can be used as novel scaffolds for drug development as antimalarial.

引用

页码：1327 / 1341

页数：15

共 50 条

[1] Fungal Anticancer Metabolites: Synthesis Towards Drug Discovery
Barbero, Margherita
Artuso, Emma
Prandi, Cristina
[J]. CURRENT MEDICINAL CHEMISTRY, 2018, 25 (02) : 141 - 185
[2] Comprehensive review on various strategies for antimalarial drug discovery
Mishra, Mitali
Mishra, Vikash K.
Kashaw, Varsha
Iyer, Arun K.
Kashaw, Sushil Kumar
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 125 : 1300 - 1320
[3] New approaches in antimalarial drug discovery and development - A Review
Aguiar, Anna Caroline C.
da Rocha, Eliana M. M.
de Souza, Nicolli B.
Franca, Tanos C. C.
Krettli, Antoniana U.
[J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2012, 107 (07): : 831 - 845
[4] Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery
Shibeshi, Melkamu Adigo
Kifle, Zemene Demelash
Atnafie, Seyfe Asrade
[J]. INFECTION AND DRUG RESISTANCE, 2020, 13 : 4047 - 4060
[5] Challenges in antimalarial drug discovery
Burrows, Jeremy N.
Leroy, Didier
Lotharius, Julie
Waterson, David
[J]. FUTURE MEDICINAL CHEMISTRY, 2011, 3 (11) : 1401 - 1412
[6] Hemozoin and antimalarial drug discovery
Fong, Kim Y.
Wright, David W.
[J]. FUTURE MEDICINAL CHEMISTRY, 2013, 5 (12) : 1437 - 1450
[7] Antimalarial Drug Resistance and Early Drug Discovery
Garcia-Bustos, Jose F.
Gamo, Francisco-Javier
[J]. CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (02) : 270 - 281
[8] Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review
Qin, Hua-Li
Zhang, Zai-Wei
Lekkala, Ravindar
Alsulami, Hamed
Rakesh, K. P.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 193
[9] A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
Kalaria, Piyush N.
Karad, Sharad C.
Raval, Dipak K.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 158 : 917 - 936
[10] Antimalarial drug discovery: progress and approaches
Siqueira-Neto, Jair L.
Wicht, Kathryn J.
Chibale, Kelly
Burrows, Jeremy N.
Fidock, David A.
Winzeler, Elizabeth A.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2023, 22 (10) : 807 - 826

← 1 2 3 4 5 →