Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil

被引：13

作者：

Slavov, Svetoslav Nanev ^{[1
,2
]}

Ciliao-Alves, Daiani Cristina ^{[3
]}

Carvalho Gonzaga, Filipe Almeida ^{[4
,5
]}

Moura, Drielly Rodrigues ^{[4
]}

Alves Melo de Moura, Ana Carolina ^{[4
]}

Goncalves de Noronha, Lorena Aparecida ^{[4
]}

Cassemiro, Evelin Mota ^{[4
,5
]}

Sidou Pimentel, Barbara Maciel ^{[6
]}

Queiroz Costa, Fabiano Jose ^{[7
]}

da Silva, Grasiela Araujo ^{[7
]}

Rabello Ramos, Doralina do Amaral ^{[8
]}

de Araujo, Wildo Navegantes ^{[4
,5
]}

Kashima, Simone ^{[1
,9
]}

Haddad, Rodrigo ^{[4
,5
]}

机构：

[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Blood Ctr Ribeirao Preto, Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, Ribeirao Preto, SP, Brazil

[3] Euroamer Univ Ctr UNIEURO, Brasilia, DF, Brazil

[4] Univ Brasilia, Fac Ceilandia, Brasilia, DF, Brazil

[5] Univ Brasilia, Ctr Trop Med, Brasilia, DF, Brazil

[6] Blood Ctr Brasilia, Brasilia, DF, Brazil

[7] Cent Publ Hlth Lab Fed Dist LACEN DF, Brasilia, DF, Brazil

[8] Univ Brasilia, Fac Hlth Sci & Med, Lab Mol Pathol Canc, Brasilia, DF, Brazil

[9] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP, Brazil

来源：

PLOS ONE | 2019年 / 14卷 / 03期

关键词：

VIRUS; VIREMIA; INFECTION; DIAGNOSIS; REGION; RNA;

D O I：

10.1371/journal.pone.0213793

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks.

引用

页数：11

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