A fidget spinner for the point-of-care diagnosis of urinary tract infection

被引：101

作者：

Michael, Issac ^{[1
,2
]}

Kim, Dongyoung ^{[2
]}

Gulenko, Oleksandra ^{[1
]}

Kumar, Sumit ^{[2
]}

Kumar, Saravana ^{[3
]}

Clara, Jothi ^{[3
]}

Ki, Dong Yeob ^{[1
]}

Park, Juhee ^{[2
]}

Jeong, Hyun Yong ^{[4
,5
,6
]}

Kim, Taek Soo ^{[7
]}

Kwon, Sunghoon ^{[4
,5
,8
,9
,10
]}

Cho, Yoon-Kyoung ^{[1
,2
]}

机构：

[1] Ulsan Natl Inst Sci & Technol UNIST, Sch Life Sci, Dept Biomed Engn, Ulsan, South Korea

[2] Inst Basic Sci IBS, Ctr Soft & Living Matter, Ulsan, South Korea

[3] Kauvery Hosp Pvt Ltd, Tiruchirappalli, India

[4] Seoul Natl Univ, Dept Transdisciplinary Studies, Seoul, South Korea

[5] Seoul Natl Univ, Inst Entrepreneurial BioConvergence, Seoul, South Korea

[6] Seoul Natl Univ, BK21 Creat Res Engineer Dev IT, Seoul, South Korea

[7] Seoul Natl Univ Hosp, Dept Lab Med, Seoul, South Korea

[8] Seoul Natl Univ, Dept Elect & Comp Engn, Seoul, South Korea

[9] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul, South Korea

[10] Seoul Natl Univ Hosp, Med Innovat Ctr, Quantamatrix Inc, Seoul, South Korea

来源：

NATURE BIOMEDICAL ENGINEERING | 2020年 / 4卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

SUSCEPTIBILITY; TECHNOLOGIES; SYSTEMS; FUTURE;

D O I：

10.1038/s41551-020-0557-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The point-of-care detection of pathogens in biological samples in resource-limited settings should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom-made fidget spinner that rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification. In Tiruchirappalli, India, the device enabled the on-site detection of infection with the naked eye within 50 min in urine samples from 39 patients suspected of having a urinary tract infection. We also show that, in 30 clinical samples of urinary tract infection, the device can be used to perform an antimicrobial susceptibility test for the antimicrobial drugs ciprofloxacin and cefazolin within 120 min. The fidget spinner could be used in low-resource settings as an inexpensive handheld point-of-care device for the rapid concentration and detection of pathogens in urine samples. A custom-made fidget spinner rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification.

引用

页码：591 / 600

页数：10

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