Glutamate evokes firing through activation of kainate receptors in chick accessory lobe neurons

被引:7
|
作者
Yamanaka, Yuko [1 ]
Kitamura, Naoki [1 ,2 ]
Shinohara, Hikaru [2 ]
Takahashi, Keita [2 ]
Shibuya, Izumi [1 ,2 ]
机构
[1] Yamaguchi Univ, United Grad Sch Vet Sci, Yamaguchi 7538515, Japan
[2] Tottori Univ, Dept Vet Physiol, Fac Agr, Tottori 6808553, Japan
基金
日本学术振兴会;
关键词
Bird; Current-clamp; Firing frequency; Ionotropic glutamate receptor; Voltage-clamp; SPINAL-CORD; MARGINAL NUCLEI; SENSE ORGAN; HAIR-CELLS; PIGEON; SPECIALIZATIONS; BIRDS;
D O I
10.1007/s00359-012-0766-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Ten pairs of protrusions, called accessory lobes (ALs), exist at the lateral sides of avian lumbosacral spinal cords. Histological and behavioral evidence suggests that neurons are present in ALs and the AL acts as a sensory organ of equilibrium during walking. Neurons in the outer layer of the AL consistently show glutamate-like immunoreactivity and neurons in the central region of the AL show glutamate receptor-like immunoreactivity. However, it is unknown how glutamate acts on the functional activity of AL neurons. In this study, we examined the effects of glutamate on the electrical activities of AL neurons using the patch clamp technique. There are two types of neurons among isolated AL neurons: spontaneously firing and silent neurons. Among silent neurons, 42 % of neurons responded to glutamate and generated repetitive firing. Kainate and glutamate in combination with the NMDA receptor antagonist, MK-801, also induced firing and evoked an inward current. On the other hand, the application of AMPA, NMDA or glutamate in combination with the non-NMDA receptor antagonist, CNQX, did not. These results indicate that chick AL neurons express functional kainate receptors to respond to glutamate and suggest that the glutamatergic transmission plays a role in excitatory regulation of AL neurons of the chick.
引用
收藏
页码:35 / 43
页数:9
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