An efficient transformation of ethers to N,N′-disubstituted ureas in a Ritter type reaction

被引：14
|
作者：
Panduranga, Veladi [1 ]
Basavaprabhu [1 ]
Sureshbabu, Vommina V. [1 ]
机构：
[1] Bangalore Univ, Peptide Res Lab, Dept Studies Chem, Dr BR Ambedkar Veedhi, Bangalore 560001, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期
关键词：
Cyanamides; Ethers; Lewis acid; N; N '-disubstituted ureas; CARBON-CARBON BONDS; CATALYZED SYNTHESIS; REDUCTIVE CARBONYLATION; OXIDATIVE CARBONYLATION; UNSYMMETRICAL UREAS; ONE-POT; AMINES; OXYGEN; INHIBITORS; DIOXIDE;
D O I：
10.1016/j.tetlet.2012.12.027
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, mild, and an alternative protocol for the preparation of N,N'-disubstituted ureas from readily available ethers and cyanamides as starting materials is described. The protocol explores the reactivity of ether in a Ritter type reaction with cyanamide in the presence of BF3 center dot Et2O and resulting in the formation of N,N'-disubstituted urea. Divinyl ether as well as MTBE (methyl tert-butyl ether) can be employed as ether components to afford allyl and tert-butyl ureas respectively. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：975 / 979
页数：5
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