Interplay between the electrostatic membrane potential and conformational changes in membrane proteins

被引：16
|
作者：
Zhang, Xuejun C. [1 ,2 ]
Li, Hang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
PROTEIN SCIENCE | 2019年 / 28卷 / 03期
基金：
中国国家自然科学基金;
关键词：
membrane protein electrostatics; membrane protein dynamics; electrostatic membrane potential; hydrophobic mismatch force; amphipathic helix; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; MULTIDRUG-RESISTANCE; POTASSIUM CHANNEL; CHARGED RESIDUES; TRANSPORTER; MECHANISM; INSIGHTS; RECEPTOR; PHOSPHATASE;
D O I：
10.1002/pro.3563
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transmembrane electrostatic membrane potential is a major energy source of the cell. Importantly, it determines the structure as well as function of charge-carrying membrane proteins. Here, we discuss the relationship between membrane potential and membrane proteins, in particular whether the conformation of these proteins is integrally connected to the membrane potential. Together, these concepts provide a framework for rationalizing the types of conformational changes that have been observed in membrane proteins and for better understanding the electrostatic effects of the membrane potential on both reversible as well as unidirectional dynamic processes of membrane proteins.
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页码：502 / 512
页数：11
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