Parkinson Syndrome(s) - New Concepts for a Spreading Disease?

被引：0
|
作者：
Klucken, J. [1 ]
Herting, B. [2 ]
Hilker, R. [3 ]
Schulz, J. B. [4 ]
Vieregge, P.
Woitalla, D. [5 ]
Wolz, M.
Reichmann, H. [6 ]
机构：
[1] Univ Klinikum Erlangen, D-91054 Erlangen, Germany
[2] Diakonie Klinikum Schwabisch, Klin Neurol & Gerontoneurol, Halle, Germany
[3] Univ Frankfurt Klinikum, Neurol Klin, Frankfurt, Germany
[4] Univ KLinikum RWTH Aachen, Neurol Klin, Aachen, Germany
[5] Ruhr Univ Bochum, Univ Klinikum, Neurol Klin, Bochum, Germany
[6] Carl Gustav Carus Univ Dresden, Neurol Klin & Poliklin, Dresden, Germany
来源：
AKTUELLE NEUROLOGIE | 2013年 / 40卷 / 06期
关键词：
Parkinson syndrome; cell-to-cell propagation; course of the disease; ALPHA-SYNUCLEIN OLIGOMERS; TO-NEURON TRANSMISSION; NONMOTOR SYMPTOMS; OLFACTORY DYSFUNCTION; NATURAL-HISTORY; NERVOUS-SYSTEM; LEWY PATHOLOGY; DIAGNOSIS; ONSET; NEURODEGENERATION;
D O I：
10.1055/s-0033-1349432
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The latest knowledge about the clinical course, pathology, and cell biological concepts in Parkinson's disease suggest a continuous spreading of both the symptoms and the underlying degeneration of the nervous system. These new concepts influence the point-of-view of physicians, pathologists, and cell biologists: they have a substantial impact on the diagnostic classification and the development of novel therapeutic options. The present article outlines the new viewpoints and controversies, and summarises the resulting scientific concepts to develop therapeutic strategies.
引用
收藏
页码：327 / 332
页数：6
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