Bioinorganic chemistry of anti-thyroid drugs: An unusual formation of a copper (II) complex

被引：10

作者：

Roy, Gouriprasanna ^{[1
]}

Nethaji, Munirathinam ^{[1
]}

Mugesh, G. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2006年 / 9卷 / 06期

关键词：

anti-thyroid drugs; copper complex; DFT calculations; lactoperoxidase inhibition activity; methimazole; selenium;

D O I：

10.1016/j.inoche.2006.02.018

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report the first example of a metal complex derived from the selenium analogue of the anti-thyroid drug methimazole (MSeI). The treatment of the diselenide form of Se-methimazole with copper (11) perchlorate leads to an unexpected deselenation reaction resulting in the formation of a novel copper (11) complex (7). Theoretical studies are performed on compounds 5 and 6 to understand the structural changes that take place at the imidazole moiety upon deselenation. In addition, glutathione peroxidase (GPx) behavior and lactoperoxidase (LPO) inhibition activities of complex 7 are described. (C) 2006 Elsevier B.V.. All rights reserved.

引用

页码：571 / 574

页数：4

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