A metadata-aware application for remote scoring and exchange of tissue microarray images

被引：1

作者：

Morris, Lorna ^{[1
,2
]}

Tsui, Andrew ^{[6
]}

Crichton, Charles ^{[6
]}

Harris, Steve ^{[6
]}

Maccallum, Peter H. ^{[1
,2
]}

Howat, William J. ^{[1
,2
]}

Davies, Jim ^{[6
]}

Brenton, James D. ^{[1
,2
,3
,4
,5
]}

Caldas, Carlos ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Dept Oncol, Cambridge CB2 0RE, England

[2] Li Ka Shing Ctr, Cambridge Res Inst, Cambridge CB2 0RE, England

[3] Li Ka Shing Ctr, Cambridge Expt Canc Med Ctr, Cambridge CB2 0RE, England

[4] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge CB2 2QQ, England

[5] NIHR Cambridge Biomed Res Ctr, Cambridge CB2 2QQ, England

[6] Univ Oxford, Dept Comp Sci, Oxford OX1 3QD, England

来源：

BMC BIOINFORMATICS | 2013年 / 14卷

关键词：

Tissue microarray; TMA; Metadata; XML; Software; BREAST-CANCER;

D O I：

10.1186/1471-2105-14-147

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The use of tissue microarrays (TMA) and advances in digital scanning microscopy has enabled the collection of thousands of tissue images. There is a need for software tools to annotate, query and share this data amongst researchers in different physical locations. Results: We have developed an open source web-based application for remote scoring of TMA images, which exploits the value of Microsoft Silverlight Deep Zoom to provide a intuitive interface for zooming and panning around digital images. We use and extend existing XML-based standards to ensure that the data collected can be archived and that our system is interoperable with other standards-compliant systems. Conclusion: The application has been used for multi-centre scoring of TMA slides composed of tissues from several Phase III breast cancer trials and ten different studies participating in the International Breast Cancer Association Consortium (BCAC). The system has enabled researchers to simultaneously score large collections of TMA and export the standardised data to integrate with pathological and clinical outcome data, thereby facilitating biomarker discovery.

引用

页数：10

共 2 条

[1] A metadata-aware application for remote scoring and exchange of tissue microarray images
Lorna Morris
Andrew Tsui
Charles Crichton
Steve Harris
Peter H Maccallum
William J Howat
Jim Davies
James D Brenton
Carlos Caldas
[J]. BMC Bioinformatics, 14
[2] Framework for parsing, visualizing and scoring tissue microarray images
Rabinovich, A
Krajewski, S
Krajewska, M
Shabaik, A
Hewitt, SM
Belongie, S
Reed, JC
Price, JH
[J]. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE, 2006, 10 (02): : 209 - 219

← 1 →