Cryptococcosis in Solid Organ Transplant Recipients: Current State of the Science

被引：144

作者：

Singh, Nina ^{[1
]}

Dromer, Francoise ^{[3
]}

Perfect, John R. ^{[2
]}

Lortholary, Olivier ^{[3
,4
]}

机构：

[1] Univ Pittsburgh, Infect Dis Sect 111E, VA Med Ctr, Pittsburgh, PA 15240 USA

[2] Duke Univ, Durham, NC USA

[3] Natl Reference Ctr Mycoses & Antifungals, Inst Pasteur, Mol Mycol Unit, Paris, France

[4] Univ Paris 05, Ctr Infectiol Necker Pasteur, Hop Necker Enfants Malad, Paris, France

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 47卷 / 10期

关键词：

D O I：

10.1086/592690

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcosis remains a significant opportunistic infection in solid organ transplant recipients. Disease presentation and outcomes may be affected by, among other factors, the use of calcineurin inhibitor immunosuppressive agents. It is being increasingly recognized that rapid reversal of immunosuppression in transplant recipients treated for cryptococcosis incurs the risk of immune reconstitution inflammatory syndrome, which resembles worsening disease or relapse. This review summarizes the current state of knowledge regarding cryptococcosis in transplant recipients and highlights areas where future investigations are needed to further optimize outcomes for these patients.

引用

页码：1321 / 1327

页数：7

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