Highly Efficient Glioma Targeting of Tat Peptide-TTA1 Aptamer-Polyephylene Glycol-Modified Gelatin-Siloxane Nanoparticles

被引：6

作者：

Lin, Xiao-Ning ^{[1
,2
]}

Tian, Xinli ^{[3
]}

Li, Wang ^{[1
,2
]}

Sun, Jin ^{[1
]}

Wei, Feng ^{[1
]}

Feng, Wei ^{[1
]}

Huang, Zhi-Chun ^{[1
]}

Tian, Xin-Hua ^{[1
]}

机构：

[1] Xiamen Univ, Zhongshan Hosp, Dept Neurosurg, Xiamen 361004, Peoples R China

[2] Xiamen Univ, Med Coll, Xiamen 361005, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp Beijing Mil, Dept Cardiovasc Dis, Beijing 100000, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2018年 / 18卷 / 04期

关键词：

Nanoparticles; Blood-Brain Barrier; Glioma; Targeted Delivery; BRAIN DRUG-DELIVERY; NUDE-MICE; IN-VIVO; PENETRATION; LIPOSOMES; TUMORS;

D O I：

10.1166/jnn.2018.14379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gliomas are the most common type of intracranial malignant tumor; however, current treatment approaches are often ineffective due to limited penetration of genes or drugs through the blood-brain barrier (BBB). Here we describe the synthesis of gelatin-siloxane nanoparticles (GS NPs) as candidate gene carriers through a two-step sol-gel process. To increase the efficiency of glioma targeting, human immunodeficiency virus-derived Tat, tumor-targeting aptamer (TTA) 1, and polyethylene glycol (PEG) were conjugated to the GS NPs to generate Tat-TTA1-PEG-GS NPs. In vivo imaging revealed that these modified NPs not only evaded capture by the reticulo-endothelial system, but were able to cross the BBB to reach gliomas. Our results suggest that Tat-TTA1-PEG-GS NPs are a new type of non-viral vector that can deliver therapeutic DNA or drugs for highly efficient glioma treatment.

引用

页码：2325 / 2329

页数：5