Characterization of Novel Human-Derived AAV2 Variants with Brain Transduction Profiles that are Comparable to AAV9

被引:0
|
作者
Xu, Meiyu [1 ,2 ]
Brown, Alexander [1 ,2 ]
Luo, Li [1 ,3 ]
Xu, Guangchao [1 ,3 ]
Qin, Wanru [3 ]
Xiao, Yuanyuan [3 ]
Wang, Chunmei [3 ]
Li, Jia [1 ]
Ma, Hong [4 ]
He, Ran [4 ]
Su, Qin [4 ]
Wei, Yuquan [3 ]
Tai, Phillip W. L. [1 ,2 ]
Gao, Guangping [1 ,2 ,4 ,5 ]
机构
[1] Univ Massachusetts, Sch Med, Horae Gene Therapy Ctr, Worcester, MA USA
[2] Univ Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA USA
[3] West China Hosp, Dept Urol, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[4] Univ Massachusetts, Sch Med, Viral Vector Core, Worcester, MA USA
[5] Univ Massachusetts, Sch Med, Li Weibo Inst Rare Dis Res, Worcester, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
169
引用
收藏
页码:89 / 90
页数:2
相关论文
共 50 条
  • [1] The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2
    Weber-Adrian, Danielle
    Heinen, Stefan
    Silburt, Joseph
    Noroozian, Zeinab
    Aubert, Isabelle
    [J]. JOURNAL OF NEUROCHEMISTRY, 2017, 140 (02) : 192 - 194
  • [2] Natural AAV2 Variants Demonstrate Stronger Neurotropism, Penetrance of the Blood-Brain Barrier, and Differential Transduction of Brain Regions Compared to AAV9
    Liu, Sophia
    Leland, Thomas
    Muhuri, Manish
    Lotun, Anoushka
    Xu, Meiyu
    Xu, Guangchao
    Luo, Li
    Qin, Wanru
    He, Ran
    Su, Qin
    Xie, Jun
    Wei, Yu-Quan
    Tai, Phillip W. L.
    Gao, Guangping
    [J]. MOLECULAR THERAPY, 2023, 31 (04) : 592 - 592
  • [3] Bioinformatic Identification and Large-Scale In Vitro and In Vivo Characterization of Human-Derived Novel AAV2 and AAV2/3 Capsid Variants Reveals Vectors with New Biological Functions
    Luo, Li
    Xu, Guangchao
    Tai, Phillip W. L.
    Qin, Wanru
    Xiao, Yuanyuan
    Wang, Chunmei
    Ma, Hong
    He, Ran
    Su, Qin
    Fong, Kaiyuen
    Gong, Shoufang
    Wei, Yuquan
    Gao, Guangping
    [J]. MOLECULAR THERAPY, 2017, 25 (05) : 231 - 231
  • [4] Engineered AAV9 Variants for Efficient Muscle Transduction
    Li, Shaoyong
    Chen, Shuyuan
    Li, Zhongwan
    Zhang, Runyuan
    Lan, Xing
    Jiang, Yuling
    Zheng, Yanyan
    Wan, Changpeng
    Pang, Xiaodong
    Wang, Lijun
    Ye, Guo-Jie
    Wu, Zhenhua
    [J]. MOLECULAR THERAPY, 2023, 31 (04) : 410 - 411
  • [5] Characterization of HSV Derived AAV9 Vectors
    Pechan, Peter
    Golebiowski, Diane
    Seregin, Alexey
    Zapata, Nicole
    Levi, Elise
    Kitsos, Christine
    Lu, Robert
    Amorrortu, Alvaro
    Morris, Carl
    [J]. MOLECULAR THERAPY, 2019, 27 (04) : 347 - 347
  • [6] Preventing PrPC Synthesis in Mice with Adeno-Associated Viral Vectors AAV2, AAV6 and AAV9
    DeArmond, Stephen
    Ahn, Misol
    Bajsarowicz, Krystyna
    Oehler, Abby
    Bankiewicz, Krystof
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (06): : 555 - 555
  • [7] AAV9 Capsid Variants with Improved CNS Transduction Identified by Directed Evolution
    Rohovie, Marcus
    Kruse, Nikki
    Schmitt, Christopher
    Wong, Victoria
    Sero, Antoinette
    Rivera-Velazquez, Mirella
    Lee, Grace
    Desautel, Sarah
    Del Greco, Elizabeth
    Sedighi, Faezeh
    Nivina, Aleksandra
    Jenne, Stephan
    Gebretsadik, Kahsay
    Kumar, Ambuj
    Chng, Chinping
    Akeefe, Hassibullah
    Silverman, Adam
    [J]. MOLECULAR THERAPY, 2023, 31 (04) : 661 - 661
  • [9] AAV9 mediates more specific cardiac gene transfer in the rat than AAV2, AAV5, AAV7, and AAV8
    Qi, Yanfei
    Liu, Xuan
    Li, Hongwei
    Shenoy, Vinayak
    Li, Qiuhong
    Hauswirth, William W.
    Sumners, Colin
    Katovich, Michael J.
    [J]. FASEB JOURNAL, 2009, 23
  • [10] Prescreening of NHP's for Neutralizing Antibodies Against Adeno Associated Virus Serotype-2 and 9 (AAV2 and AAV9)
    Dhawan, Rajeev K.
    Balzer, Connor
    Campbell, Lachelle
    Mendoza, Marta
    Dovan, John
    Jennings, Steve
    Nicholson, Donald
    [J]. MOLECULAR THERAPY, 2022, 30 (04) : 85 - 85