Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)

被引：99
|
作者：
Kochanek, Matthias [1 ,2 ,3 ]
Schalk, E. [3 ,4 ]
von Bergwelt-Baildon, M. [3 ,5 ,6 ]
Beutel, G. [3 ,7 ]
Buchheidt, D. [3 ,8 ]
Hentrich, M. [9 ]
Henze, L. [3 ,10 ]
Kiehl, M. [3 ,11 ]
Liebregts, T. [3 ,12 ]
von Lilienfeld-Toal, M. [13 ]
Classen, A. [1 ,2 ]
Mellinghoff, S. [1 ,2 ]
Penack, O. [14 ]
Piepel, C. [15 ]
Boell, B. [1 ,2 ,3 ]
机构：
[1] Univ Cologne, Fac Med, Dept Internal Med 1, Kerpener Str 62, D-50937 Cologne, Germany
[2] Univ Cologne, Univ Hosp Cologne, Kerpener Str 62, D-50937 Cologne, Germany
[3] iCHOP, Cologne, Germany
[4] Otto von Guericke Univ, Med Ctr, Dept Hematol & Oncol, Magdeburg, Germany
[5] Univ Med Ctr, Med Dept 3, Munich, Germany
[6] Comprehens Canc Ctr Munich, Munich, Germany
[7] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany
[8] Mannheim Univ Hosp, Dept Hematol & Oncol, Mannheim, Germany
[9] Red Cross Hosp, Dept ofMedicine Hematol & Oncol 3, Munich, Germany
[10] Rostock Univ, Med Ctr, Dept Med, Clin Hematol Oncol Palliat Med 3, Rostock, Germany
[11] Clin Frankfurt Oder, Dept Internal Med 1, Frankfurt, Germany
[12] Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Dept Bone Marrow Transplantat, Essen, Germany
[13] Univ Hosp Jena, Dept Hematol & Med Oncol, Jena, Germany
[14] Charite Univ Med Berlin, Campus Virchow Clin, Dept Hematol Oncol & Tumorimmunol, Berlin, Germany
[15] Klinikum Bremen Mitte, Dept Hematol Oncol & Infect Dis, Bremen, Germany
来源：
ANNALS OF HEMATOLOGY | 2019年 / 98卷 / 05期
关键词：
Guideline; Sepsis; Septic shock; Cancer; Neutropenia; Management; ACUTE RESPIRATORY-FAILURE; CRITICALLY-ILL PATIENTS; LONG-TERM OUTCOMES; AMINOGLYCOSIDE COMBINATION THERAPY; BETA-LACTAM MONOTHERAPY; C-REACTIVE PROTEIN; SEPTIC SHOCK; IMMUNOCOMPROMISED PATIENTS; NONINVASIVE VENTILATION; PROSPECTIVE MULTICENTER;
D O I：
10.1007/s00277-019-03622-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sepsis and septic shock are major causes of mortality during chemotherapy-induced neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting characteristics and prompt management is most important. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. However, optimal management may differ between neutropenic and non-neutropenic patients. The aim of the current guideline is to give evidence-based recommendations for hematologists, oncologists, and intensive care physicians on how to manage adult patients with neutropenia and sepsis.
引用
收藏
页码：1051 / 1069
页数：19
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