Anti-Human Coronavirus (anti-HCoV) Triterpenoids from the Leaves of Euphorbia neriifolia

被引：1

作者：

Chang, Fang-Rong ^{[4
]}

Yen, Chiao-Ting ^{[4
]}

El-Shazly, Mohamed ^{[4
,5
]}

Lin, Wen-Hsun ^{[4
]}

Yen, Ming-Hong ^{[6
]}

Lin, Kuei-Hsiang ^{[7
]}

Wu, Yang-Chang ^{[1
,2
,3
]}

机构：

[1] China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung 40402, Taiwan

[2] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung 40402, Taiwan

[3] China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan

[5] Ain Shams Univ, Dept Pharmacognosy & Nat Prod Chem, Fac Pharm, Cairo 11566, Egypt

[6] Kaohsiung Med Univ, Coll Pharm, Kaohsiung 80708, Taiwan

[7] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 80708, Taiwan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 11期

关键词：

Euphorbia neriifolia; Euphorbiaceae; Human coronaviruses (HCoVs); Triterpenoids; Structure-activity relationship (SAR); H-1;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Euphorbia neriifolia L. is a spiny herb native to Southeast Asia and currently cultivated in southern Taiwan. From the ethanolic extract of E. neriifolia leaves, 23 compounds were isolated, including 22 triterpenoids and one flavonoid glycoside. The anti-human coronavirus (HCoV) activity of the separated triterpenoids was studied revealing the structure-activity relationship (SAR) of these isolates. 3 beta-Friedelanol exhibited more potent anti-viral activity than the positive control, actinomycin D, which implies the importance of the friedelane skeleton as a potential scaffold for developing new anti-HCoV-229E drugs.

引用

页码：1415 / 1417

页数：3

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