Role of the PTEN signaling pathway in autism spectrum disorder

被引：18

作者：

Lv, Jing-Wen ^{[1
]}

Cheng, Tian-Lin ^{[2
]}

Qiu, Zi-Long ^{[2
]}

Zhou, Wen-Hao ^{[1
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PTEN; TSC; 1/2; autism; synapse; neural stem cells; TUBEROUS SCLEROSIS COMPLEX; LHERMITTE-DUCLOS-DISEASE; IN-VIVO; MOUSE MODEL; SOMA SIZE; CELLS; TSC1; GENE; PREVALENCE; DELETION;

D O I：

10.1007/s12264-013-1382-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism is an etiologically heterogeneous group of neurodevelopmental disorders, diagnosed mostly by the clinical behavioral phenotypes. The concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last decade. In this review, we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry, as well as genetic mouse models with Pten manipulations. Particularly, accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

引用

页码：773 / 778

页数：6

共 50 条

[1] Role of the PTEN signaling pathway in autism spectrum disorder
Jing-Wen Lv
Tian-Lin Cheng
Zi-Long Qiu
Wen-Hao Zhou
NeuroscienceBulletin, 2013, 29 (06) : 773 - 778
[2] Role of the PTEN signaling pathway in autism spectrum disorder
Jing-Wen Lv
Tian-Lin Cheng
Zi-Long Qiu
Wen-Hao Zhou
Neuroscience Bulletin, 2013, 29 : 773 - 778
[3] The role of PTEN signaling in synaptic function: Implications in autism spectrum disorder
Nagy, Gabriela Spina
Kawamoto, Elisa Mitiko
Bridi, Jessika Cristina
NEUROSCIENCE LETTERS, 2021, 759
[4] PTEN signaling in autism spectrum disorders
Zhou, Jing
Parada, Luis F.
CURRENT OPINION IN NEUROBIOLOGY, 2012, 22 (05) : 873 - 879
[5] Unraveling the Role of Wnt Signaling Pathway in the Pathogenesis of Autism Spectrum Disorder (ASD): A Systematic Review
Bou Najm, Daniel
Alame, Saada
Takash Chamoun, Wafaa
MOLECULAR NEUROBIOLOGY, 2025, 62 (04) : 4971 - 4992
[6] The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder
Bae, Seung Min
Hong, Ji Yeon
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 2018, 16 (02) : 129 - 135
[7] mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder
Drehmer, Isabela
Santos-Terra, Julio
Gottfried, Carmem
Deckmann, Iohanna
NEUROSCIENCE, 2024, 563 : 33 - 42
[8] Does the kynurenine pathway play a pathogenic role in autism spectrum disorder?
Santana-Coelho, Danielle
BRAIN BEHAVIOR & IMMUNITY-HEALTH, 2024, 40
[9] Autism Spectrum Disorder Associated with Germline Heterozygous PTEN Mutations
Frazier, Thomas W.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019, 9 (10):
[10] Developmental Pleiotropy of PTEN in Congenital Hydrocephalus and Autism Spectrum Disorder
DeSpenza, Tyrone
NEUROSURGERY, 2019, 66 : 61 - 61

← 1 2 3 4 5 →