Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones

被引：17

作者：

Sun, Xiaohua ^{[1
]}

Fei, Jie ^{[1
]}

Zou, Chuncheng ^{[1
]}

Lu, Min ^{[1
]}

Ye, Jinxing ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Minist Educ, Shanghai Key Lab New Drug Design, Engn Res Ctr Pharmaceut Proc Chem,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 108期

基金：

中国国家自然科学基金;

关键词：

SULFA-MICHAEL ADDITION; ALPHA; BETA-UNSATURATED KETONES; ENANTIOSELECTIVE CONSTRUCTION; ORGANOCASCADE CATALYSIS; VINYL KETONES; PRIMARY AMINE; SPIROOXINDOLES; ACTIVATION; ENONES; FUNCTIONALIZATION;

D O I：

10.1039/c6ra19916j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolnethiones have been realized by employing a cinchona-based primary amine catalyst. This method displays a broad substrate scope and provides a simple and highly effective way to achieve the chiral spiro[thiopyranoindole-cyclohexanone] scaffold.

引用

页码：106676 / 106679

页数：4

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