Distribution of purinergic P2X receptors in the rat heart

被引：32

作者：

Hansen, MA

Bennett, MR ^{[1
]}

Barden, JA

机构：

[1] Univ Sydney, Inst Biomed Res, Sydney, NSW 2006, Australia

[2] Univ Sydney, Dept Anat & Histol, Sydney, NSW 2006, Australia

[3] Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1999年 / 78卷 / 01期

基金：

英国医学研究理事会;

关键词：

varicosities; ATP; cardiac; neurotransmission;

D O I：

10.1016/S0165-1838(99)00046-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of P2X purinergic receptor subtypes has been determined in relation to nerve varicosities in the rat heart with immunohistochemistry. Large clusters (about 1 mu m diameter) of co-localised and sometimes co-extensive P2X(1) and P2X(3) receptors were found at sites of tyrosine hydroxylase (TH) positive axon varicosities in the atrium and the ventricle. Varicosities that were labelled with antibodies to the synaptic vesicle epitope SV2 were frequently labelled also with antibodies to P2X(3), P2X(5) and P2X(6) but not always with antibodies to P2X(1). Especially prominent were large numbers of small clusters (about 400 nm diameter) of co-localised P2X(2) and P2X(5) receptors on the sarcolemma unrelated to nerves at all. During development the 1 day-old heart possessed an abundance of co-localised P2X(2) and P2X(5) small receptor clusters on the sarcolemma. These observations are discussed in relation to the role of purinergic receptors in the mammalian heart. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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