Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones .1. Synthesis and in vitro antimicrobial evaluation

被引：0
|
作者：
Bruni, F [1 ]
Selleri, S [1 ]
Costanzo, A [1 ]
Guerrini, G [1 ]
Casilli, NL [1 ]
Sacco, C [1 ]
Donato, R [1 ]
机构：
[1] UNIV FLORENCE,DIPARTIMENTO SANITA PUBBL EPIDEMIOL & CHIM ANALIT,I-50134 FLORENCE,ITALY
来源：
FARMACO | 1996年 / 51卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (9-36) was prepared by a simple synthetic procedure based on the reaction of ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (1-8) and reagents (a-n) containing a primary amino group. When this set of compounds was subjected to ''in vitro'' antimicrobial screening, it showed no significant activity.
引用
收藏
页码：451 / 455
页数：5
相关论文
共 50 条
  • [1] Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation
    Bruni, F
    Selleri, S
    Costanzo, A
    Guerrini, G
    Ciciani, G
    Costagli, C
    Sacco, C
    Donato, R
    FARMACO, 1997, 52 (10): : 639 - 643
  • [2] A NEW ENTRY TO PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES
    BRUNI, F
    CHIMICHI, S
    COSIMELLI, B
    COSTANZO, A
    GUERRINI, G
    SELLERI, S
    HETEROCYCLES, 1990, 31 (06) : 1141 - 1149
  • [3] SYNTHESIS AND PRELIMINARY EVALUATION OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDIN-6(7H)-ONES AND RELATED-COMPOUNDS, AS BENZODIAZEPINE RECEPTOR LIGANDS AND ANTICONVULSANT AGENTS
    SELLERI, S
    BRUNI, F
    COSTANZO, A
    GUERRINI, G
    AIELLO, PM
    IAVARONE, G
    MARTINI, C
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (09) : 985 - 990
  • [4] REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL)PYRAZOLO[1,5-A]PYRIMIDINES - SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS .1.
    BRUNI, F
    SELLERI, S
    COSTANZO, A
    GUERRINI, G
    CASILLI, ML
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (05) : 1193 - 1198
  • [5] PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE - A NEW HETEROCYCLIC RING-SYSTEM
    BRUNI, F
    CHIMICHI, S
    COSIMELLI, B
    COSTANZO, A
    GUERRINI, G
    SELLERI, S
    HETEROCYCLES, 1990, 31 (09) : 1635 - 1640
  • [6] REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL)PYRAZOLO[1,5-A]PYRIMIDINES - SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS .2.
    BRUNI, F
    SELLERI, S
    COSTANZO, A
    GUERRINI, G
    CASILLI, ML
    GIUSTI, L
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (01) : 291 - 298
  • [7] Routes to pyrazolo[3,4-e][1,4]thiazepine, pyrazolo[1,5-a]pyrimidine and pyrazole derivatives
    Abu Elmaati, TM
    El-Taweel, FMA
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2003, 50 (3A) : 413 - 418
  • [8] REACTIONS WITH HETEROCYCLIC AMIDINES - SYNTHESIS OF PYRAZOLO[3,4-E]THIAZEPINE, PYRAZOLO[1,5-C] 1,2,4-TRIAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES
    SOFAN, MA
    ELTAWEEL, FMA
    ELMAATI, TMA
    ELAGAMEY, AA
    PHARMAZIE, 1994, 49 (07): : 482 - 486
  • [9] Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship
    Ivachtchenko, Alexandre V.
    Golovina, Elena S.
    Kadieva, Madina G.
    Kysil, Volodymyr M.
    Mitkin, Oleg D.
    Vorobiev, Anton A.
    Okun, Ilya
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (13) : 4273 - 4280
  • [10] Synthesis of pyrazolo[3,4-b]pyridine and pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine derivatives
    El-Enany, Mervat M.
    El-Meligie, Salwa E. M.
    Abdou, Nadia A.
    El-Nassan, Hala B.
    JOURNAL OF CHEMICAL RESEARCH, 2010, (08) : 470 - 474
12345