Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Background. Studies suggest an association betweenH. pyloriinfection and extragastrointestinal disease. Limited studies provided conflicting results on the association betweenH. pyloriinfection and diabetes. The present study was aimed at examining the association betweenH. pyloriinfection and diabetes in a large health checkup population in China.Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included.H. pyloriinfection was diagnosed by(13)C-urea breath test. Multivariate logistic regression analysis was performed to evaluate the association betweenH. pyloriinfection and diabetes.Results. The mean age of 13,397 participants was 43.8 +/- 12 years. The prevalence ofH. pyloriinfection and diabetes was 28.2% and 8.1%, respectively. The prevalence of diabetes was higher amongH. pylori-positive participants compared with their counterparts (8.9% vs 7.8%, p = 0.05). After adjustment of age, sex, family history of diabetes, smoking, education, stroke, coronary heart disease, BMI, SBP, TG, HDL-C, and LDL-C, multivariate logistic regression analysis found no association between H. pylori infection and diabetes (OR 1.02, 95% CI 0.88-1.18). Additionally, subgroup analysis indicated thatH. pyloriinfection was significantly associated with increased risk of diabetes in the female group (OR 1.09, 95% CI 1.08-1.09).Conclusions. No significant association was found betweenH. pyloriinfection and diabetes. However, the subgroup analysis suggested thatH. pyloriinfection was possibly associated with increased risk of diabetes among females. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes.