IL-10 SINGLE NUCLEOTIDE POLYMORPHISMS AND LUPUS-NEPHRITIS

被引：0

作者：

Dourmishev, Lyubomir ^{[3
]}

Hristova, Maria ^{[4
]}

Vinkov, Anton ^{[5
]}

Kamenarska, Zornitsa ^{[1
,2
]}

Kaneva, Radka ^{[1
,2
]}

Baleva, Marta ^{[4
]}

Mitev, Vanio ^{[1
,2
]}

机构：

[1] Med Univ Sofia, Mol Med Ctr, Sofia, Bulgaria

[2] Med Univ Sofia, Dept Med Chem & Biochem, Sofia, Bulgaria

[3] Med Univ Sofia, Dept Dermatol & Venereol, Sofia, Bulgaria

[4] Med Univ Sofia, Dept Clin Lab & Clin Immunol, Sofia, Bulgaria

[5] Med Diagnost & Consulting Ctr 28, Sofia, Bulgaria

来源：

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2012年 / 26卷 / 03期

关键词：

IL-10; polymorphisms; lupus-nephritis; case-control study; INTERLEUKIN-10 PROMOTER POLYMORPHISMS; BLOOD MONONUCLEAR-CELLS; CYTOKINE PRODUCTION; PERIPHERAL-BLOOD; ERYTHEMATOSUS SLE; DISEASE; REGION; ASSOCIATION; HAPLOTYPES; MAPS;

D O I：

10.5504/BBEQ.2012.0036

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A pilot study was carried out to investigate the association of five single nucleotide polymorphisms of the IL-10 gene (-3575T/A, -2849G/A, -2763C/A, -1082G/A, -592C/A) with the risk of lupus-nephritis in Bulgarian female patients. We found a strong association between the -592 AA and CA genotypes (P = 0.009, OR 4.38, 95%CI 1.4-13.6) and the A allele (P = 0.037, OR 2.25, 95%CI 1-5) with the disease. Although statistically insignificant, the frequency of the IL-10 -3575TT, -2763CC, -2849GG and -1082GG genotypes was higher in the patients compared to the controls, which resulted in an increased odds ratio (OR). The haplotype analysis revealed an association between the IL-10 -3575T/-2849G/-2763C/-592A haplotype and lupus-nephritis (P = 0.04).

引用

页码：2991 / 2993

页数：3

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