Time Course of Islet Loss after Intraportal Transplantation

被引：7
|
作者：
Pawelec, Krystian [1 ]
Juszczak, Maciej Tadeusz [1 ]
Kumar, Anila [1 ]
Powis, Steve Hugh [1 ]
Press, Martin [1 ]
机构：
[1] Royal Free & Univ Coll Med Sch, Univ Coll London, Dept Endocrinol & Diabet, Royal Free Hampstead NHS Trust & Ctr Nephrol, London NW3 2PE, England
来源：
Immunology of Diabetes V: From Bench to Bedside | 2008年 / 1150卷
关键词：
pancreatic islet transplantation; islet survival; diabetes; selective intraportal transplantation; islet:bead ratio;
D O I：
10.1196/annals.1447.016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A high percentage of islets fail to survive intraportal transplantation, but the absolute amount and time course of this loss are uncertain. We have devised a technique to directly quantitate the number of surviving islets using simultaneous selective transplantation of islets and inert beads into the posterior lobes of the liver. Islet:bead ratio did not change significantly within the first 2 hours, but fell progressively thereafter, giving calculated islet survival rates of 89, 43, and 66% at days 1, 7 and 28, respectively. This technique provides a baseline from which to develop strategies to improve the survival of intraportally transplanted islets.
引用
收藏
页码：230 / 233
页数：4
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