Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype

被引：23
|
作者：
Siriwardana, A.
Iyengar, K.
Roepe, P. D. [1 ]
机构：
[1] Georgetown Univ, Dept Chem & Biochem, Washington, DC 20057 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 11期
基金：
美国国家卫生研究院;
关键词：
ANTIMALARIAL ACTIVITY; WESTERN CAMBODIA; MALARIA; PHARMACOKINETICS; DIHYDROARTEMISININ; ARTESUNATE; ARTEMETHER; QUANTIFICATION; VOLUNTEERS; PARASITES;
D O I：
10.1128/AAC.00857-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ring-stage susceptibility assay was modified to quantify the susceptibilities of multiple strains of control and delayed-clearance phenotype (DCP) Plasmodium falciparum strains to seven endoperoxide antimalarial drugs. The susceptibility of all of the DCP lines to six of the drugs was lower than that of the controls. In contrast, DCP parasites did not show reduced susceptibility to the synthetic endoperoxide drug OZ439. These data show that it is possible to circumvent emerging artemisinin resistance with a modified endoperoxide drug.
引用
收藏
页码：6952 / 6956
页数：5
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