Hepatitis E Virus Genotype 3 in Wild Rats, United States

被引：80
|
作者：
Lack, Justin B. [1 ]
Volk, Kylie [1 ]
Van den Bussche, Ronald A. [1 ]
机构：
[1] Oklahoma State Univ, Dept Zool, Stillwater, OK 74075 USA
来源：
EMERGING INFECTIOUS DISEASES | 2012年 / 18卷 / 08期
基金：
美国国家科学基金会;
关键词：
BLOOD-DONORS; WIDESPREAD INFECTION; PREVALENCE; ANTIBODIES; COUNTRIES; RISK; USA; SEROREACTIVITY; CALIFORNIA; RODENTS;
D O I：
10.3201/eid1808.120070
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
引用
收藏
页码：1268 / 1273
页数：6
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